Issue 67, 2020, Issue in Progress

Microwave assisted synthesis of negative-charge carbon dots with potential antibacterial activity against multi-drug resistant bacteria

Abstract

In this research, negative-charge carbon dots (CDs) were synthesized in one-step using a microwave and found to have potential antibacterial ability against multi-drug resistant bacteria. The CDs were synthesized by using citric acid and urea as precursors, and characterized by FT-IR, TEM and fluorescence spectrophotometry. The average size of CDs was about 2.5 nm, and the ζ potential was −11.06 mV. In the following antibacterial activity test, time-killing curve experiments and colony-forming assay were carried out to determine the minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC) of the CDs against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-intermediate Staphylococcus aureus (VISA). The data showed the MBC of the CDs against MRSA is 2.5 mg mL−1, and the MIC of the CDs against MRSA is 0.63 mg mL−1; the MBC of the CDs against VISA is 1.25 mg mL−1, and the MIC of the CDs against VISA is 0.63 mg mL−1. The results demonstrated that the negative-charge CDs have potential against multi-drug resistant Staphylococcus aureus (S. aureus), and may serve as alternatives for therapy in the future.

Graphical abstract: Microwave assisted synthesis of negative-charge carbon dots with potential antibacterial activity against multi-drug resistant bacteria

Article information

Article type
Paper
Submitted
18 Aug 2020
Accepted
15 Oct 2020
First published
11 Nov 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 41202-41208

Microwave assisted synthesis of negative-charge carbon dots with potential antibacterial activity against multi-drug resistant bacteria

J. Kung, I. Tseng, C. Chien, S. Lin, C. Wang and C. Shih, RSC Adv., 2020, 10, 41202 DOI: 10.1039/D0RA07106D

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