Jump to main content
Jump to site search

Issue 63, 2020, Issue in Progress
Previous Article Next Article

Simultaneous determination of methadone and morphine at a modified electrode with 3D β-MnO2 nanoflowers: application for pharmaceutical sample analysis

Author affiliations

Abstract

The present research synthesized manganese dioxide nano-flowers (β-MnO2-NF) via a simplified technique for electro-catalytic utilization. Moreover, morphological characteristics and X-ray analyses showed Mn in the oxide form with β-type crystallographic structure. In addition, the research proposed a new efficient electro-chemical sensor to detect methadone at the modified glassy carbon electrode (β-MnO2-NF/GCE). It has been found that oxidizing methadone is irreversible and shows a diffusion controlled procedure at the β-MnO2-NF/GCE. Moreover, β-MnO2-NF/GCE was considerably enhanced in the anodic peak current of methadone related to the separation of morphine and methadone overlapping voltammetric responses with probable difference of 510 mV. In addition, a linear increase has been observed between the catalytic peak currents gained by the differential pulse voltammetry (DPV) of morphine and methadone and their concentrations in the range between 0.1–200.0 μM and 0.1–250.0 μM, respectively. Furthermore, the limits of detection (LOD) for methadone and morphine were found to be 5.6 nM and 8.3 nM, respectively. It has been found that our electrode could have a successful application for detecting methadone and morphine in the drug dose form, urine, and saliva samples. Thus, this condition demonstrated that β-MnO2-NF/GCE displays good analytical performances for the detection of methadone.

Graphical abstract: Simultaneous determination of methadone and morphine at a modified electrode with 3D β-MnO2 nanoflowers: application for pharmaceutical sample analysis

Back to tab navigation

Article information


Submitted
26 Jul 2020
Accepted
01 Oct 2020
First published
19 Oct 2020

This article is Open Access

RSC Adv., 2020,10, 38532-38545
Article type
Paper

Simultaneous determination of methadone and morphine at a modified electrode with 3D β-MnO2 nanoflowers: application for pharmaceutical sample analysis

S. Akbari, S. Jahani, M. M. Foroughi and H. Hassani Nadiki, RSC Adv., 2020, 10, 38532
DOI: 10.1039/D0RA06480G

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements