Issue 48, 2020, Issue in Progress

A sensitive BODIPY-based fluorescent probe for detecting endogenous hydroxyl radicals in living cells

Abstract

The hydroxyl radical (˙OH) has been suggested to play very vital roles in many physiological and pathological processes. However, selective detection of ˙OH is highly challenging owing to its extremely high reactivity and short lifetime. Herein, we designed and synthesized a sensitive “turn on” fluorescent probe for detecting endogenous ˙OH based on a BODIPY (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) platform. The probe had shown good properties including high sensitively, ideal selectively and low cytotoxicity, and was successfully employed to image endogenous hydroxyl radical in living cells.

Graphical abstract: A sensitive BODIPY-based fluorescent probe for detecting endogenous hydroxyl radicals in living cells

Supplementary files

Article information

Article type
Paper
Submitted
19 Jun 2020
Accepted
29 Jul 2020
First published
04 Aug 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 28705-28710

A sensitive BODIPY-based fluorescent probe for detecting endogenous hydroxyl radicals in living cells

X. Qu, Y. Bian, Y. Chen and X. Wei, RSC Adv., 2020, 10, 28705 DOI: 10.1039/D0RA05378C

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