Issue 42, 2020

A concise method for fully automated radiosyntheses of [18F]JNJ-46356479 and [18F]FITM via Cu-mediated 18F-fluorination of organoboranes

Abstract

A modified alcohol-enhanced 18F-fluorodeboronation has been developed for the radiosyntheses of [18F]JNJ-46356479 and [18F]FITM. Unlike the [18F]KF/K222 approach, this method tolerates the presence of sensitive heterocycles in Bpin precursors 4 and 8 allowing a one-step 18F-fluorodeboronation on the fully automated TRACERlab™ FXFN platform.

Graphical abstract: A concise method for fully automated radiosyntheses of [18F]JNJ-46356479 and [18F]FITM via Cu-mediated 18F-fluorination of organoboranes

Supplementary files

Article information

Article type
Paper
Submitted
04 Jun 2020
Accepted
25 Jun 2020
First published
02 Jul 2020
This article is Open Access
Creative Commons BY license

RSC Adv., 2020,10, 25223-25227

A concise method for fully automated radiosyntheses of [18F]JNJ-46356479 and [18F]FITM via Cu-mediated 18F-fluorination of organoboranes

G. Yuan, T. M. Shoup, S. Moon and A. Brownell, RSC Adv., 2020, 10, 25223 DOI: 10.1039/D0RA04943C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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