Issue 43, 2020, Issue in Progress
From the journal:

RSC Advances

Visible-light promoted three-component tandem reaction to synthesize difluoromethylated oxazolidin-2-imine†

Kun Bao,‡ab   Jun Wei,‡a   Huihui Yanab  and  Rong Sheng ORCID logo *a  

* Corresponding authors

a College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, People's Republic of China
E-mail: shengr@zju.edu.cn

b Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, P. R. China

Abstract

An effective synthetic method to achieve difluoromethylated oxazolidin-2-imine has been developed via visible-light promoted three-component tandem reaction of aryl allylamines, 2-BTSO2CF2H (BT = Benzothiazole) and isocyanates. This method features mild reaction conditions and good functional group tolerance, and the reaction mechanism was confirmed by experiments and interpreted by quantum chemical calculations.

Graphical abstract: Visible-light promoted three-component tandem reaction to synthesize difluoromethylated oxazolidin-2-imine

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Article information

DOI
https://doi.org/10.1039/D0RA04729E
Article type
Paper
Submitted
29 May 2020
Accepted
25 Jun 2020
First published
09 Jul 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 25947-25951

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Visible-light promoted three-component tandem reaction to synthesize difluoromethylated oxazolidin-2-imine

K. Bao, J. Wei, H. Yan and R. Sheng, RSC Adv., 2020, 10, 25947 DOI: 10.1039/D0RA04729E

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