Issue 41, 2020, Issue in Progress

1,3-Dipolar cycloaddition of isatin N,N′-cyclic azomethine imines with α,β-unsaturated aldehydes catalyzed by DBU in water

Abstract

A simple and green procedure was established by [3 + 3] cycloaddition reaction of isatin derived cyclic imine 1,3-dipoles with α,β-unsaturated aldehydes, giving the desired spiro heterocyclic oxindoles with aza-quaternary centers in good yields and diastereoselectivities. It should be noted that water can be employed as a suitable solvent for the improvement of diastereoselectivity.

Graphical abstract: 1,3-Dipolar cycloaddition of isatin N,N′-cyclic azomethine imines with α,β-unsaturated aldehydes catalyzed by DBU in water

Supplementary files

Article information

Article type
Paper
Submitted
28 Apr 2020
Accepted
18 Jun 2020
First published
25 Jun 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 24288-24292

1,3-Dipolar cycloaddition of isatin N,N′-cyclic azomethine imines with α,β-unsaturated aldehydes catalyzed by DBU in water

Z. Wang, T. Yang, R. Chen, X. Ma, H. Liu and K. Wang, RSC Adv., 2020, 10, 24288 DOI: 10.1039/D0RA03806G

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