Issue 36, 2020, Issue in Progress
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RSC Advances

Synthesis, structure, and antitumor activity of 2,9-disubstituted perhydro 2,3a,7b,9,10a,14b-hexaazadibenzotetracenes†

Elena B. Rakhimova, ORCID logo *a   Victor Yu. Kirsanov, ORCID logo a   Elena V. Tret'yakova,a   Leonard M. Khalilov, ORCID logo a   Askhat G. Ibragimov,a   Lilya U. Dzhemileva,*a   Vladimir A. D'yakonova  and  Usein M. Dzhemileva  

* Corresponding authors

a Institute of Petrochemistry and Catalysis, Russian Academy of Sciences, 141 Prospekt Oktyabrya, 450075 Ufa, Russian Federation
E-mail: rakhimovaelena@mail.ru, dzhemilev@mail.ru

Abstract

Catalytic methods for the synthesis of previously unknown 2,9-disubstituted 3bR*,7aR*,10bR*,14aR*-cis-14c,14d-perhydro-2,3a,7b,9,10a,14b-hexaazadibenzotetracenes have been developed. The structures were established by 1D (1H, 13C) and 2D (COSY, HSQC, HMBC) NMR spectroscopy, MALDI TOF/TOF mass spectrometry, and X-ray diffraction analysis. Primary screening of the synthesized perhydro hexaazadibenzotetracenes for antitumor activity was carried out.

Graphical abstract: Synthesis, structure, and antitumor activity of 2,9-disubstituted perhydro 2,3a,7b,9,10a,14b-hexaazadibenzotetracenes

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Article information

DOI
https://doi.org/10.1039/D0RA03209C
Article type
Paper
Submitted
09 Apr 2020
Accepted
19 May 2020
First published
04 Jun 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 21039-21048

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Synthesis, structure, and antitumor activity of 2,9-disubstituted perhydro 2,3a,7b,9,10a,14b-hexaazadibenzotetracenes

E. B. Rakhimova, V. Yu. Kirsanov, E. V. Tret'yakova, L. M. Khalilov, A. G. Ibragimov, L. U. Dzhemileva, V. A. D'yakonov and U. M. Dzhemilev, RSC Adv., 2020, 10, 21039 DOI: 10.1039/D0RA03209C

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