Issue 29, 2020, Issue in Progress
From the journal:

RSC Advances

Concise asymmetric synthesis of two natural oxacyclododecindione-type macrolactones from industrial waste†

Xian Liu,a   Huifang Nie,a   Lin Yao,a   Ru Jiang ORCID logo *a  and  Weiping Chen ORCID logo *a  

* Corresponding authors

a School of Pharmacy, Fourth Military Medical University, 169 Changle West Road, Xian, P. R. China
E-mail: jiangru@fmmu.edu.cn

Abstract

(S)-5-Methyl-tetrahydropyran-2-one 1 is a by-product in the production of key intermediates of steroidal hormones. Asymmetric synthesis of natural oxacyclododecindione-type macrolactones 2 and 3 has been realized for the first time from (S)-1 in seven and eight steps with 37% and 27% overall yield, respectively.

Graphical abstract: Concise asymmetric synthesis of two natural oxacyclododecindione-type macrolactones from industrial waste

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Article information

DOI
https://doi.org/10.1039/D0RA02994G
Article type
Paper
Submitted
02 Apr 2020
Accepted
21 Apr 2020
First published
30 Apr 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 16882-16885

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Concise asymmetric synthesis of two natural oxacyclododecindione-type macrolactones from industrial waste

X. Liu, H. Nie, L. Yao, R. Jiang and W. Chen, RSC Adv., 2020, 10, 16882 DOI: 10.1039/D0RA02994G

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