Jump to main content
Jump to site search

Issue 25, 2020, Issue in Progress
Previous Article Next Article

Enhancing cellular morphological changes and ablation of cancer cells via the interaction of drug co-loaded magnetic nanosystems in weak rotating magnetic fields

Author affiliations

Abstract

Magnetic nanoparticles have been widely used in cancer treatment for their potential magnetic functions and synergistic antitumor effect with therapeutic agents. In this work, we developed a polymeric nanosystem by co-loading the natural anticancer drug tetrandrine and superparamagnetic iron oxide nanoparticles for cancer combinatorial therapy. The nanosystem possessed regular morphology and superior magnetic properties. Under the action of external rotating permanent magnets, the nanosystem could transfer a rotational motion to damage the cellular membrane, which would result in the increased permeabilization of the cell membrane and damage to lysosomes. Hence, the specific characteristics of the magnetic nanosystem induced potent cytotoxicity and enhanced the effect of the tetrandrine-induced cell apoptosis. With further exploration, we found that this nanoplatform caused cell death via a lysosomal-mitochondrial apoptotic pathway with the upregulation of proapoptotic proteins (Cathepsin B, Smac/Diablo, Cytochrome C, and Caspase 3) and the down-regulation of antiapoptotic proteins (Bcl-2 and XIAP). These findings demonstrate that the combination therapy mediated by co-loaded magnetic nanosystems can be used for a multi-therapeutic effect against tumors in biomedical applications.

Graphical abstract: Enhancing cellular morphological changes and ablation of cancer cells via the interaction of drug co-loaded magnetic nanosystems in weak rotating magnetic fields

Back to tab navigation

Article information


Submitted
15 Feb 2020
Accepted
25 Mar 2020
First published
16 Apr 2020

This article is Open Access

RSC Adv., 2020,10, 14471-14481
Article type
Paper

Enhancing cellular morphological changes and ablation of cancer cells via the interaction of drug co-loaded magnetic nanosystems in weak rotating magnetic fields

T. Wu, Q. Zhang, H. Hu, F. Yang, K. Li, Y. Zhang and C. Shi, RSC Adv., 2020, 10, 14471
DOI: 10.1039/D0RA01458C

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements