Issue 23, 2020

Nitrileimines as an alternative to azides in base-mediated click [3 + 2] cycloaddition with methylene active nitriles

Abstract

Nitrileimines were implemented in practical click protocols with oxopropanenitriles for the straightforward 5-amino-1H-pyrazole synthesis via 1,3-dipolar cycloaddition. The reaction proceeds at room temperature in a short time with base catalysis and no chromatographic purification. High purity products were isolated by simple filtration. The selectivity of the reaction was observed.

Graphical abstract: Nitrileimines as an alternative to azides in base-mediated click [3 + 2] cycloaddition with methylene active nitriles

Supplementary files

Article information

Article type
Paper
Submitted
13 Feb 2020
Accepted
20 Mar 2020
First published
03 Apr 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 13696-13699

Nitrileimines as an alternative to azides in base-mediated click [3 + 2] cycloaddition with methylene active nitriles

M. A. Tupychak, O. Ya. Shyyka, N. T. Pokhodylo and M. D. Obushak, RSC Adv., 2020, 10, 13696 DOI: 10.1039/D0RA01417F

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