Issue 24, 2020
From the journal:

RSC Advances

Efficient Cu-catalyzed intramolecular O-arylation for synthesis of benzoxazoles in water†

Yanling Tang,‡a   Minxin Li,‡a   Hui Gao,*a   Gaoxiong Raoa  and  Zewei Mao ORCID logo *a  

* Corresponding authors

a College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming 650500, P.R. China
E-mail: gaohui_em@126.com, ydmason@163.com, maozw@ynutcm.edu.cn
Fax: +86 871 65918232
Tel: +86 871 65918232

Abstract

An efficient method was developed for synthesis of benzoxazoles by Cu-catalyzed intramolecular O-arylation of o-halobenzanilides in water. This strategy provides several advantages, such as high yields, water as a green solvent and functional groups tolerance.

Graphical abstract: Efficient Cu-catalyzed intramolecular O-arylation for synthesis of benzoxazoles in water

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Article information

DOI
https://doi.org/10.1039/D0RA00570C
Article type
Paper
Submitted
19 Jan 2020
Accepted
28 Mar 2020
First published
07 Apr 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 14317-14321

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Efficient Cu-catalyzed intramolecular O-arylation for synthesis of benzoxazoles in water

Y. Tang, M. Li, H. Gao, G. Rao and Z. Mao, RSC Adv., 2020, 10, 14317 DOI: 10.1039/D0RA00570C

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