Heterogeneous graph inference based on similarity network fusion for predicting lncRNA–miRNA interaction

Abstract

LncRNA and miRNA are two non-coding RNA types that are popular in current research. LncRNA interacts with miRNA to regulate gene transcription, further affecting human health and disease. Accurate identification of lncRNA–miRNA interactions contributes to the in-depth study of the biological functions and mechanisms of non-coding RNA. However, relying on biological experiments to obtain interaction information is time-consuming and expensive. Considering the rapid accumulation of gene information and the few computational methods, it is urgent to supplement the effective computational models to predict lncRNA–miRNA interactions. In this work, we propose a heterogeneous graph inference method based on similarity network fusion (SNFHGILMI) to predict potential lncRNA–miRNA interactions. First, we calculated multiple similarity data, including lncRNA sequence similarity, miRNA sequence similarity, lncRNA Gaussian nuclear similarity, and miRNA Gaussian nuclear similarity. Second, the similarity network fusion method was employed to integrate the data and get the similarity network of lncRNA and miRNA. Then, we constructed a bipartite network by combining the known interaction network and similarity network of lncRNA and miRNA. Finally, the heterogeneous graph inference method was introduced to construct a prediction model. On the real dataset, the model SNFHGILMI achieved AUC of 0.9501 and 0.9426 ± 0.0035 based on LOOCV and 5-fold cross validation, respectively. Furthermore, case studies also demonstrate that SNFHGILMI is a high-performance prediction method that can accurately predict new lncRNA–miRNA interactions. The Matlab code and readme file of SNFHGILMI can be downloaded from https://github.com/cj-DaSE/SNFHGILMI.