Issue 10, 2020

Synthesis of anti-allergic drugs

Abstract

Histamine is formed by the decarboxylation of histidine catalyzed by enzymes. It is an endogenous biologically active substance involved in multiple complex physiological processes as an important chemical transmitter. Histamine receptors have four subtypes, H1, H2, H3 and H4, all of which are G protein coupling receptors (GPCRs) with different physiological functions. Histamine plays an important role in the pathophysiological mechanism of allergic diseases, and the antagonistic effect of histamine has become an important way to study anti-allergic drugs, wherein the anti-allergic drugs used in clinical practice are mainly H1 receptor antagonists. Currently, there are many varieties of H1 receptor antagonists in clinical applications, which can be divided into ethylenediamine antagonists, amino ether antagonists, propylamine antagonists, tricyclic antagonists, piperazine antagonists and piperidine antagonists depending on their chemical structures. This article mainly reviews the research progress of allergic reactions with histamine H1 receptor antagonists and expounds the important aspects of the design and synthesis of various new compounds.

Graphical abstract: Synthesis of anti-allergic drugs

Article information

Article type
Review Article
Submitted
18 Dec 2019
Accepted
20 Jan 2020
First published
04 Feb 2020
This article is Open Access
Creative Commons BY license

RSC Adv., 2020,10, 5874-5885

Synthesis of anti-allergic drugs

S. Zhou and G. Huang, RSC Adv., 2020, 10, 5874 DOI: 10.1039/C9RA10659F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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