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Issue 26, 2020, Issue in Progress
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Synthesis of new N,N′-Pd(Pt) complexes based on sulfanyl pyrazoles, and investigation of their in vitro anticancer activity

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Abstract

The synthesis of new N,N′-mononuclear bi-ligand Pd(II) and tri-ligand Pt(II)complexes bearing sulfanyl(phenyl, benzyl, cyclohexyl, 4-hydroxyphenyl)3,5-dimethyl-1H-pyrazole ligands has been carried out. The obtained compounds were studied for apoptosis-inducing activity and effect on the cell cycle for Jurkat, K562, and U937 neoplastic cell cultures and conditionally normal human embryonic kidney HEK293 cells. The cells showed the highest sensitivity to platinum and palladium complexes in comparison with ligands and cisplatin. The cytotoxic properties are enhanced for compounds with cyclohexyl substituents at the S-atom in sulfanyl pyrazoles and complexes.

Graphical abstract: Synthesis of new N,N′-Pd(Pt) complexes based on sulfanyl pyrazoles, and investigation of their in vitro anticancer activity

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Article information


Submitted
22 Nov 2019
Accepted
24 Mar 2020
First published
17 Apr 2020

This article is Open Access

RSC Adv., 2020,10, 15116-15123
Article type
Paper

Synthesis of new N,N′-Pd(Pt) complexes based on sulfanyl pyrazoles, and investigation of their in vitro anticancer activity

V. R. Akhmetova, N. S. Akhmadiev, M. F. Abdullin, L. U. Dzhemileva and V. A. D'yakonov, RSC Adv., 2020, 10, 15116
DOI: 10.1039/C9RA09783J

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