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Issue 14, 2020
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Design and in vitro/in vivo evaluations of a multiple-drug-containing gingiva disc for periodontotherapy

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Abstract

In the current work, we set out to develop and evaluate a gingiva disc of cellulose acetate phthalate and poloxamer F-127 for the simultaneous delivery of multiple drugs, namely minocycline, celecoxib, doxycycline hyclate, and simvastatin, to abolish infection, impede inflammation, avert collagen destruction, and promote alveolar bone regeneration, respectively. In vitro release studies revealed the sustained release profiles of the drugs for 12 h and that they were active against Staphylococcus aureus, Escherichia coli and Streptococcus mutans. The in vivo bioactivity levels of these drugs were assessed by comparing the number of colony forming units during different phases of a study on Wistar rats, and the results showed a reduction in the number of bacterial colonies with the applied formulation. A mucosal irritation study conducted on Wistar rat gingiva confirmed the non-irritancy of the optimal gingiva disc. Hence, this customized, non-invasive polymeric gingiva disc displaying a sustained release of drugs can be a useful tool to treat acute to moderate stages of periodontitis.

Graphical abstract: Design and in vitro/in vivo evaluations of a multiple-drug-containing gingiva disc for periodontotherapy

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Supplementary files

Article information


Submitted
16 Nov 2019
Accepted
10 Feb 2020
First published
27 Feb 2020

This article is Open Access

RSC Adv., 2020,10, 8530-8538
Article type
Paper

Design and in vitro/in vivo evaluations of a multiple-drug-containing gingiva disc for periodontotherapy

P. Jain, Mohd. A. Mirza, S. Talegaonkar, S. Nandy, M. Dudeja, N. Sharma, Md. K. Anwer, S. M. Alshahrani and Z. Iqbal, RSC Adv., 2020, 10, 8530 DOI: 10.1039/C9RA09569A

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