Issue 8, 2020
From the journal:

RSC Advances

Rose bengal as photocatalyst: visible light-mediated Friedel–Crafts alkylation of indoles with nitroalkenes in water†

Zong-Yi Yu,ab   Jing-Nan Zhao,ab   Fan Yang,ab   Xiao-Fei Tang,ab   Yu-Feng Wu,ab   Cun-Fei Ma,ab   Bo Song,ab   Lei Yunab  and  Qing-Wei Meng ORCID logo *ab  

* Corresponding authors

a State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian 116024, P. R. China

b Dalian University of Technology, Dalian 116024, P. R. China
E-mail: mengqw@dlut.edu.cn

Abstract

A novel and facile visible-light-mediated alkylation of indoles and nitroalkenes has been developed. In this protocol, rose bengal acts as a photosensitizer, and environmentally benign water was used as the green and efficient reaction medium. Indoles reacted smoothly with nitroalkenes under the irradiation of visible-light and generated corresponding 3-(2-nitroalkyl)indoles in moderate to good yields (up to 87%).

Graphical abstract: Rose bengal as photocatalyst: visible light-mediated Friedel–Crafts alkylation of indoles with nitroalkenes in water

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Article information

DOI
https://doi.org/10.1039/C9RA09227G
Article type
Paper
Submitted
07 Nov 2019
Accepted
21 Jan 2020
First published
29 Jan 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 4825-4831

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Rose bengal as photocatalyst: visible light-mediated Friedel–Crafts alkylation of indoles with nitroalkenes in water

Z. Yu, J. Zhao, F. Yang, X. Tang, Y. Wu, C. Ma, B. Song, L. Yun and Q. Meng, RSC Adv., 2020, 10, 4825 DOI: 10.1039/C9RA09227G

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