Strontium ranelate-loaded POFC/β-TCP porous scaffolds for osteoporotic bone repair

Abstract

It is of considerable significance to fabricate scaffolds with satisfactory osteogenic activities and high osteogenesis quality to accelerate osteoporotic repair. In this study, we initially fabricated the POFC/β-TCP porous scaffold in the light of composition and structure bionics, and then loaded the SR to the optimized POFC/β-TCP porous scaffold by 3D printing based on FFS-MDJ. The hydrophilicity, mechanical properties biodegradability and cell response of the composite scaffolds were systematically investigated. The result showed that modified POFC enhanced the hydrophilicity and ameliorated the brittleness of pure β-TCP. β-TCP buffered the acidity and improved the degradability and cell affinity of the scaffold, and the release of strontium ranelate significantly promote the proliferation and differentiation of osteoblasts and guided bone regeneration. The results indicated that POFC/β-TCP scaffolds had uniform macropores of 300–500 μm and a porosity of approximately 48%, adjustable biodegradability and a high compressive modulus of 30–60 MPa. The strontium ranelate-loaded POFC/β-TCP scaffold enhanced the osteogenic differentiation of rBMSCs, which might be a promising candidate for osteoporotic-related bone defect repair.