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Issue 20, 2020
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Rhodium(iii)-catalyzed carboxylate-directed ortho-selective thiolation of benzoic acids

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Abstract

A regioselective rhodium-catalyzed carboxylate-directed thiolation process was developed. Several benzoic-acid derivatives and disulfides were found to be well-tolerated, and they yielded the corresponding products in moderate to good yields. Compounds such as the key precursor of roflumilast can be obtained via this reaction, thereby highlighting the potential of this synthetic approach.

Graphical abstract: Rhodium(iii)-catalyzed carboxylate-directed ortho-selective thiolation of benzoic acids

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Article information


Submitted
07 Aug 2020
Accepted
12 Sep 2020
First published
18 Sep 2020

Org. Chem. Front., 2020,7, 3229-3233
Article type
Research Article

Rhodium(III)-catalyzed carboxylate-directed ortho-selective thiolation of benzoic acids

D. Wang, K. Zhou, J. Zhang and Y. Zhao, Org. Chem. Front., 2020, 7, 3229
DOI: 10.1039/D0QO00940G

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