A one-pot three-component strategy for highly diastereoselective synthesis of spirocycloalkane fused pyrazolo[3,4-b]pyridine derivatives using recyclable solid acid as a catalyst

Abstract

An efficient and eco-friendly approach for highly diastereoselective synthesis of spirocycloalkane fused pyrazolo[3,4-b]pyridine derivatives has been developed. The one-pot three-component reaction enables multiple bond-forming events including C–C and C–N bonds under mild conditions using easily available starting materials, leading to diastereoselective generation of N-containing spirocycles. The advantages of inexpensive and easily available starting materials, green and mild reaction conditions, recyclable and easily separable heterogeneous catalysts, broad substrate scope and simple one-pot operation make this strategy highly attractive.