Issue 15, 2020
From the journal:

Organic Chemistry Frontiers

Oxidative cascade cyclization of 2-cyano-3-arylaniline derived acrylamides with toluenes, ethers, aliphatic alcohols or simple alkanes†

Wen-Jin Xia,a   Yangchun Xin,b   Zhi-Wei Zhao,a   Xin Chen,a   Xiang-Xiang Wang,a   Yi Li,a   Guanlin Wanga  and  Ya-Min Li ORCID logo *a  

* Corresponding authors

a Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P. R. China
E-mail: liym@kust.edu.cn

b Katzin Diagnostic & Research PET/MR Center, Nemours/Alfred I. DuPont Hospital for Children, Wilmington, DE 19803, USA

Abstract

An oxidative radical cascade cyclization of 2-cyano-3-arylaniline derived acrylamides with hydrocarbons is described. The present reaction exhibits a wide substrate scope, and toluenes, ethers, aliphatic alcohols and simple alkanes can be employed as coupling partners, providing access to alkyl substituted pyrido[4,3,2-gh]phenanthridines.

Graphical abstract: Oxidative cascade cyclization of 2-cyano-3-arylaniline derived acrylamides with toluenes, ethers, aliphatic alcohols or simple alkanes

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Article information

DOI
https://doi.org/10.1039/D0QO00535E
Article type
Research Article
Submitted
08 May 2020
Accepted
16 Jun 2020
First published
16 Jun 2020

Org. Chem. Front., 2020,7, 1997-2002

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Oxidative cascade cyclization of 2-cyano-3-arylaniline derived acrylamides with toluenes, ethers, aliphatic alcohols or simple alkanes

W. Xia, Y. Xin, Z. Zhao, X. Chen, X. Wang, Y. Li, G. Wang and Y. Li, Org. Chem. Front., 2020, 7, 1997 DOI: 10.1039/D0QO00535E

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