Issue 5, 2020

Intervaginal space injection of a liquid metal can prevent breast cancer invasion and better-sustain concomitant resistance

Abstract

Chest wall (CW) invasion by recurrent or locally advanced breast cancer (BC) requires further treatment with more potential complications. The negative margin of a tumor has been proposed as a critical factor in BC surgery; however, the ideal margin remains controversial, and data suggest that this parameter cannot further reduce CW invasion. Herein, a liquid metal (LM) was introduced as an interstitial stream (IS) to separate the BC and CW to prevent tumor invasion into the CW. Successful continuous separation and the prevention of CW invasion were observed in 4T1 tumor-bearing mice by magnetic resonance imaging (MRI) and anatomical observation, respectively. Furthermore, the inhibition of primary tumor growth and the prevention of accelerated secondary tumor growth suggest that this method potently retains concomitant resistance (CR). Subsequently, the enhanced maturation of dendritic cells (DCs) from the LM group suggests that this method may activate T cell-dependent immunity to retain CR through DC maturation. Additionally, LM was shown to have limited toxicity. In this study, LM was introduced as an IS into the interstitial space, which potentially links superficial and deep sites in the body, and showed excellent ability to prevent CW invasion, thus also providing a potential way to efficiently deliver drugs.

Graphical abstract: Intervaginal space injection of a liquid metal can prevent breast cancer invasion and better-sustain concomitant resistance

Article information

Article type
Research Article
Submitted
12 Dec 2019
Accepted
17 Jan 2020
First published
30 Mar 2020
This article is Open Access
Creative Commons BY-NC license

Mater. Chem. Front., 2020,4, 1397-1403

Intervaginal space injection of a liquid metal can prevent breast cancer invasion and better-sustain concomitant resistance

Y. Cao, X. Hu, Q. Zhang, W. Hua, N. Hu, Y. Nie, X. Xu, Y. Xu, C. Yang, X. Zhou, W. Liu and D. Han, Mater. Chem. Front., 2020, 4, 1397 DOI: 10.1039/C9QM00753A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements