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Issue 5, 2020
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Multifunctional cubic liquid crystalline nanoparticles for chemo- and photodynamic synergistic cancer therapy

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Abstract

With the aim of engineering multifunctional nanoparticles useful for cancer therapy, a diketopyrrolopyrrole-porphyrin based photosensitizer was here conjugated to a block copolymer (Pluronic F108), and used to stabilize in water lipidic cubic liquid crystalline nanoparticles (cubosomes), also loaded with the antineoplastic agent docetaxel. The physicochemical characterization by SAXS, DLS, and cryo-TEM demonstrated that the formulation consisted of cubosomes, about 150 nm in size, possessing a bicontinuous cubic structure (space group Pn3m). The cellular imaging experiments proved that these nanoparticles localized in lysosomes and mitochondria, while cytotoxicity tests evidenced a slight but significant synergistic effect which, after irradiation, increased the toxicity induced by docetaxel alone, allowing further reduction of cell viability.

Graphical abstract: Multifunctional cubic liquid crystalline nanoparticles for chemo- and photodynamic synergistic cancer therapy

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Supplementary files

Article information


Submitted
16 Nov 2019
Accepted
07 Apr 2020
First published
15 Apr 2020

Photochem. Photobiol. Sci., 2020,19, 674-680
Article type
Paper

Multifunctional cubic liquid crystalline nanoparticles for chemo- and photodynamic synergistic cancer therapy

S. Jenni, G. Picci, M. Fornasier, M. Mamusa, J. Schmidt, Y. Talmon, A. Sour, V. Heitz, S. Murgia and C. Caltagirone, Photochem. Photobiol. Sci., 2020, 19, 674
DOI: 10.1039/C9PP00449A

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