Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles

Takunori Harada; Hiraku Matsuzaki; Ryohei Oyama; Takuma Takeuchi; Tomoaki Takei; Taisuke Ninomiya; Kouta Takami; Takanori Inoue; Hiroyasu Nishiguchi; Emi Hifumi; Hiroyuki Shinto; Hiromi Takahashi; Kazuo Umemura

doi:10.1039/C9PP00356H

Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles†

Takunori Harada,

*^a Hiraku Matsuzaki,^a Ryohei Oyama,^a Takuma Takeuchi,^a Tomoaki Takei,^a Taisuke Ninomiya,^a Kouta Takami,^a Takanori Inoue,^a Hiroyasu Nishiguchi,^b Emi Hifumi,^b Hiroyuki Shinto,

^c Hiromi Takahashi^d and Kazuo Umemura^e

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* Corresponding authors

^a Department of Integrated Science and Technology, Faculty of Science and Technology, Oita University, Dannoharu, 700, Oita city 870-1192, Japan
E-mail: tharada@oita-u.ac.jp
Tel: +81-(0)97-554-7622

^b Research Promotion Institute, Oita University, Dannoharu, 700, Oita city 870-1192, Japan

^c Department of Chemical Engineering, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan

^d System instruments Co. Ltd, 776-2, Komiya, Hachioji, Tokyo 192-0031, Japan

^e Tokyo University of Science, 1-3 Kagurazaka, Shinjuku, Tokyo, Japan

Abstract

We demonstrate amyloid fibril (AF) decomposition induced by NIR-active upconversion nanoparticles complexed with photosensitisers. The process is triggered by upconversion, which initiates a photochemical reaction cascade that culminates in the generation of the highly reactive singlet-oxygen product ¹O₂ close to the amyloid superstructures, resulting in AF decomposition.

Photochemical & Photobiological Sciences

Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles†

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