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Issue 1, 2021
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Fusarochromene, a novel tryptophan-derived metabolite from Fusarium sacchari

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Abstract

Fusarochromene isolated from the plant pathogenic fungus, Fusarium sacchari is closely related to a group of mycotoxins including fusarochromanone previously isolated from various Fusaria spp. Despite their assumed polyketide biogenesis, incorporation studies with 13C-labelled acetate, glycerol and tryptophans show that fusarochromene is unexpectedly derived via oxidative cleavage of the aromatic amino acid tryptophan. A putative biosynthetic gene cluster has been identified.

Graphical abstract: Fusarochromene, a novel tryptophan-derived metabolite from Fusarium sacchari

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Supplementary files

Article information


Submitted
05 Oct 2020
Accepted
22 Oct 2020
First published
23 Oct 2020

This article is Open Access

Org. Biomol. Chem., 2021,19, 182-187
Article type
Paper

Fusarochromene, a novel tryptophan-derived metabolite from Fusarium sacchari

J. W. Marshall, K. M. J. de Mattos-Shipley, I. A. Y. Ghannam, A. Munawar, J. C. Killen, C. M. Lazarus, R. J. Cox, C. L. Willis and T. J. Simpson, Org. Biomol. Chem., 2021, 19, 182
DOI: 10.1039/D0OB02031A

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