Rhodium(iii)-catalyzed C4-amidation of indole-oximes with dioxazolones via C–H activation

Abstract

A novel method for the Rh(III)-catalyzed oxime-directed C–H amidation of indoles with dioxazolones has been developed. This strategy provides an exclusive site selectivity and the directing group can be easily removed. This transformation features a wide substrate scope, good functional group tolerance and excellent yields, and may serve as a significant tool to construct structurally diverse indole derivatives for the screening of potential pharmaceuticals in the future.