Issue 39, 2020
From the journal:

Organic & Biomolecular Chemistry

Rhodium(iii)-catalyzed C4-amidation of indole-oximes with dioxazolones via C–H activation†

Shi-Biao Tang,‡a   Xiao-Pan Fu,‡a   Gao-Rong Wu,a   Li-Li Zhang,a   Ke-Zuan Deng,a   Jin-Yue Yang,a   Cheng-Cai Xia ORCID logo *b  and  Ya-Fei Ji ORCID logo *a  

* Corresponding authors

a Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education; School of Pharmacy, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, P. R. China
E-mail: jyf@ecust.edu.cn

b Pharmacy College, Shandong First Medical University & Shandong Academy of Medical Sciences, 619 Changcheng Road, Taian 271016, P. R. China
E-mail: xiachc@163.com

Abstract

A novel method for the Rh(III)-catalyzed oxime-directed C–H amidation of indoles with dioxazolones has been developed. This strategy provides an exclusive site selectivity and the directing group can be easily removed. This transformation features a wide substrate scope, good functional group tolerance and excellent yields, and may serve as a significant tool to construct structurally diverse indole derivatives for the screening of potential pharmaceuticals in the future.

Graphical abstract: Rhodium(iii)-catalyzed C4-amidation of indole-oximes with dioxazolones via C–H activation

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D0OB01655A
Article type
Paper
Submitted
10 Aug 2020
Accepted
18 Sep 2020
First published
01 Oct 2020

Org. Biomol. Chem., 2020,18, 7922-7931

Permissions

Request permissions

Rhodium(III)-catalyzed C4-amidation of indole-oximes with dioxazolones via C–H activation

S. Tang, X. Fu, G. Wu, L. Zhang, K. Deng, J. Yang, C. Xia and Y. Ji, Org. Biomol. Chem., 2020, 18, 7922 DOI: 10.1039/D0OB01655A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements