Issue 29, 2020
From the journal:

Organic & Biomolecular Chemistry

Sulfur-mediated annulation of 1,2-phenylenediamines towards benzofuro- and benzothieno-quinoxalines†

Loan T. Tran,‡ab   Tuan H. Ho, ORCID logo ‡ab   Nhu T. A. Phan,ab   Tung T. Nguyen ORCID logo *ab  and  Nam T. S. Phan ORCID logo *ab  

* Corresponding authors

a Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet, District 10, Ho Chi Minh City, Vietnam
E-mail: tungtn@hcmut.edu.vn, ptsnam@hcmut.edu.vn

b Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc District, Ho Chi Minh City, Vietnam

Abstract

We report a method for condensation between ortho-phenylenediamines and ortho-hydroxyacetophenones to afford benzofuroquinoxalines. The reactions proceeded in the presence of an elemental sulfur mediator, DABCO base, and DMSO solvent. Functionalities such as nitrile, ester, and halogen groups were compatible. The conditions could be applicable for the synthesis of benzothienoquinoxalines from ortho-chloroacetophenones.

Graphical abstract: Sulfur-mediated annulation of 1,2-phenylenediamines towards benzofuro- and benzothieno-quinoxalines

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D0OB00887G
Article type
Paper
Submitted
29 Apr 2020
Accepted
01 Jul 2020
First published
10 Jul 2020

Org. Biomol. Chem., 2020,18, 5652-5659

Permissions

Request permissions

Sulfur-mediated annulation of 1,2-phenylenediamines towards benzofuro- and benzothieno-quinoxalines

L. T. Tran, T. H. Ho, N. T. A. Phan, T. T. Nguyen and N. T. S. Phan, Org. Biomol. Chem., 2020, 18, 5652 DOI: 10.1039/D0OB00887G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements