Issue 17, 2020

KI/TBHP-promoted [3 + 2] cycloaddition of pyrrolo[1,2-a]quinoxalines and N-arylsulfonylhydrazones

Abstract

An efficient KI/TBHP-promoted [3 + 2] cycloaddition of pyrrolo[1,2-a]quinoxalines and N-tosylhydrazones is described. A series of diverse fused [1,2,4]triazolo[3,4-c]quinoxalines was obtained in moderate to good yields with wide functional group tolerance. Importantly, this reaction can be performed on a gram scale, even in a one-pot fashion. In addition, further transformations of the products were also investigated.

Graphical abstract: KI/TBHP-promoted [3 + 2] cycloaddition of pyrrolo[1,2-a]quinoxalines and N-arylsulfonylhydrazones

Supplementary files

Article information

Article type
Paper
Submitted
08 Mar 2020
Accepted
14 Apr 2020
First published
14 Apr 2020

Org. Biomol. Chem., 2020,18, 3360-3366

KI/TBHP-promoted [3 + 2] cycloaddition of pyrrolo[1,2-a]quinoxalines and N-arylsulfonylhydrazones

Z. Yang, J. He, Y. Wei, W. Li and P. Liu, Org. Biomol. Chem., 2020, 18, 3360 DOI: 10.1039/D0OB00494D

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