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Recent progress in the total synthesis of marine brominated sesquiterpene aplydactone

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Abstract

Aplydactone is a brominated sesquiterpene isolated from the sea hare Aplysia dactylomela. Structurally, it features a complex cage-like skeleton containing a highly strained tricyclic-[4.2.0.03,8]-4-decanone system. Its unique structural features have fascinated many synthetic chemists. In this review, the synthetic efforts towards aplydactone in the last five years are summarized in two categories including nonbiomimetic synthesis and biomimetic synthesis based on the core synthetic strategy. These syntheses set a classical and instructive example for the syntheses of other marine natural products.

Graphical abstract: Recent progress in the total synthesis of marine brominated sesquiterpene aplydactone

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Article information


Submitted
12 Dec 2019
Accepted
13 Jan 2020
First published
13 Jan 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Review Article

Recent progress in the total synthesis of marine brominated sesquiterpene aplydactone

R. Chen, S. Yang and Y. Zhang, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/C9OB02642H

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