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The iboga enigma: the chemistry and neuropharmacology of iboga alkaloids and related analogs

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Abstract

Covering: 2000 up to 2020

Few classes of natural products have inspired as many chemists and biologists as have the iboga alkaloids. This family of monoterpenoid indole alkaloids includes the anti-addictive compound ibogaine as well as catharanthine, a precursor to the chemotherapeutic vinblastine. Despite being known for over 120 years, these small molecules continue to challenge our assumptions about biosynthetic pathways, catalyze our creativity for constructing complex architectures, and embolden new approaches for treating mental illness. This review will cover recent advances in both the biosynthesis and chemical synthesis of iboga alkaloids as well as their use as next-generation neurotherapeutics. Whenever appropriate, we provide historical context for the discoveries of the past decade and indicate areas that have yet to be resolved. While significant progress regarding their chemistry and pharmacology has been made since the 1960s, it is clear that the iboga alkaloids will continue to stoke scientific innovation for years to come.

Graphical abstract: The iboga enigma: the chemistry and neuropharmacology of iboga alkaloids and related analogs

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Article information


Submitted
05 Jun 2020
First published
14 Aug 2020

Nat. Prod. Rep., 2020, Advance Article
Article type
Review Article

The iboga enigma: the chemistry and neuropharmacology of iboga alkaloids and related analogs

R. N. Iyer, D. Favela, G. Zhang and D. E. Olson, Nat. Prod. Rep., 2020, Advance Article , DOI: 10.1039/D0NP00033G

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