A highly sensitive ratiometric fluorescent probe for imaging endogenous hydrogen sulfide in cells

Abstract

Hydrogen sulfide has been shown to play important regulatory roles in more and more physiological and pathological processes. Therefore, it is necessary to develop highly sensitive, selective and reliable probes for detecting hydrogen sulfide to reveal its specific role in the progression of certain diseases. Here, a novel ratiometric fluorescent probe for imaging hydrogen sulfide was designed by connecting the azide group with the N-methylquinoline quaternary ammonium salt through a styrene group. This probe has high selectivity and good sensitivity, and can image the changes of endogenous hydrogen sulfide in living cells.