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Issue 47, 2020
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Nanohybrids of shuttle-like α-Fe2O3 nanoparticles and nitrogen-doped graphene for simultaneous voltammetric detection of dopamine and uric acid

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Abstract

In this study, an ultrasensitive voltammetric sensor was constructed for the simultaneous detection of dopamine (DA) and uric acid (UA) using shuttle-like α-Fe2O3 nanoparticle/nitrogen-doped graphene nanocomposites (Fe2O3–NG). The surface morphologies, crystalline structures, and electrochemical properties of Fe2O3–NG were investigated by scanning electron microscopy, powder X-ray diffraction, cyclic voltammetry, and AC impedance spectroscopy. Coupling shuttle-like α-Fe2O3 with NG nanosheets not only enlarges the electrochemically active surface area and prevents the agglomeration of α-Fe2O3 NPs or NG nanosheets, but also increases the electroconductivity of α-Fe2O3 NPs and boosts its catalytic ability, thereby affording more electroactive sites for the adsorption and oxidation of target analytes. As expected, the Fe2O3–NG/GCE shows extraordinary electrocatalytic oxidation capacities toward DA and UA over two wide dynamical response concentration ranges of 0.5–10 μM and 10–100 μM, with low detection limits (LOD) of 0.080 and 0.075 μM for DA and UA, respectively. Moreover, the Fe2O3–NG/GCE shows high anti-interference ability against several potential interferences and retains stable voltammetric responses for at least a week. Finally, the Fe2O3–NG/GCE achieves the simultaneous determination of DA and UA in human serum with reliable results.

Graphical abstract: Nanohybrids of shuttle-like α-Fe2O3 nanoparticles and nitrogen-doped graphene for simultaneous voltammetric detection of dopamine and uric acid

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Supplementary files

Article information


Submitted
16 Sep 2020
Accepted
10 Nov 2020
First published
11 Nov 2020

New J. Chem., 2020,44, 20797-20805
Article type
Paper

Nanohybrids of shuttle-like α-Fe2O3 nanoparticles and nitrogen-doped graphene for simultaneous voltammetric detection of dopamine and uric acid

H. Liu, R. Xiong, P. Zhong, G. Li, J. Liu, J. Wu, Y. Liu and Q. He, New J. Chem., 2020, 44, 20797
DOI: 10.1039/D0NJ04629A

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