Needle stochastic sensors for on-site fast recognition and quantification of biomarkers for gastric cancer in biological samples

Abstract

There is a high request for fast, simultaneous, and early on-site detection of different biomarkers in order to facilitate early diagnostic and personalized treatment of gastric cancer. Therefore, in this paper we proposed a fast screening method based on two needle stochastic sensors modified with chitosan (n = 371–744) for the assay of CA19-9, p53, and CEA in biological samples. The limits of determination obtained for the proposed needle stochastic sensors are lower than for any other method proposed to date; simultaneous assay of the biomarkers was possible from whole blood, saliva and tumoral tissue samples on-site, the results being available within minutes.