Issue 34, 2020
From the journal:

New Journal of Chemistry

Cu-catalyzed cyclization to construct indoles from N-(ortho-chloromethyl)aryl carbamates and terminal alkynes via a one-pot reaction†

Yang Shi, ORCID logo ‡ab   Gangqiang Wang,‡ac   Hang Wang,ab   Bin Deng,ab   Tao Gao,a   Jian Wang,a   Haibing Guo,a   Minghu Wu*a  and  Shaofa Sun*a  

* Corresponding authors

a Hubei Key Laboratory of Radiation Chemistry and Functional Materials, Non-power Nuclear Technology Collaborative Innovation Center, School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning 437100, China
E-mail: sunshaofa@hbust.edu.cn

b School of Pharmacy, Hubei University of Science and Technology, Xianning 437100, China

c School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China

Abstract

In this reaction, a new strategy for the synthesis of indoles from N-(ortho-chloromethyl)aryl carbamates and terminal alkynes via Cu-catalyzed coupling–cyclization has been developed. The reactions proceeded smoothly under mild conditions with a wide functional group tolerance.

Graphical abstract: Cu-catalyzed cyclization to construct indoles from N-(ortho-chloromethyl)aryl carbamates and terminal alkynes via a one-pot reaction

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Article information

DOI
https://doi.org/10.1039/D0NJ01981J
Article type
Paper
Submitted
20 Apr 2020
Accepted
24 Jul 2020
First published
06 Aug 2020

New J. Chem., 2020,44, 14477-14480

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Cu-catalyzed cyclization to construct indoles from N-(ortho-chloromethyl)aryl carbamates and terminal alkynes via a one-pot reaction

Y. Shi, G. Wang, H. Wang, B. Deng, T. Gao, J. Wang, H. Guo, M. Wu and S. Sun, New J. Chem., 2020, 44, 14477 DOI: 10.1039/D0NJ01981J

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