Cu-catalyzed cyclization to construct indoles from N-(ortho-chloromethyl)aryl carbamates and terminal alkynes via a one-pot reaction†
Abstract
In this reaction, a new strategy for the synthesis of indoles from N-(ortho-chloromethyl)aryl carbamates and terminal alkynes via Cu-catalyzed coupling–cyclization has been developed. The reactions proceeded smoothly under mild conditions with a wide functional group tolerance.