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Issue 34, 2020
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Cu-catalyzed cyclization to construct indoles from N-(ortho-chloromethyl)aryl carbamates and terminal alkynes via a one-pot reaction

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Abstract

In this reaction, a new strategy for the synthesis of indoles from N-(ortho-chloromethyl)aryl carbamates and terminal alkynes via Cu-catalyzed coupling–cyclization has been developed. The reactions proceeded smoothly under mild conditions with a wide functional group tolerance.

Graphical abstract: Cu-catalyzed cyclization to construct indoles from N-(ortho-chloromethyl)aryl carbamates and terminal alkynes via a one-pot reaction

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Article information


Submitted
20 Apr 2020
Accepted
24 Jul 2020
First published
06 Aug 2020

New J. Chem., 2020,44, 14477-14480
Article type
Paper

Cu-catalyzed cyclization to construct indoles from N-(ortho-chloromethyl)aryl carbamates and terminal alkynes via a one-pot reaction

Y. Shi, G. Wang, H. Wang, B. Deng, T. Gao, J. Wang, H. Guo, M. Wu and S. Sun, New J. Chem., 2020, 44, 14477
DOI: 10.1039/D0NJ01981J

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