Synthesis of sulfonium N-chloramines for antibacterial applications

Abstract

For the first time sulfonium N-chloramines were chemically synthesized, which displayed significantly higher biocidal efficacy than the previously reported quaternary ammonium counterpart. Noticeable synergistic biocidal efficacy was observed between the dodecyl chain tethered sulfonium centre and the N-chloramine moiety, exerting the highest antibacterial efficacy so far of all cationic N-chloramines.