POP-Pd(ii) catalyzed easy and safe in situ carbonylation towards the synthesis of α-ketoamides from secondary cyclic amines utilizing CHCl3 as a carbon monoxide surrogate

Abstract

A novel complex catalyst, POP-palladium(II), has been synthesized. The developed catalyst has been characterized by XRD, EDX, scanning electron microscopy (FE-SEM), HR-TEM, FTIR spectroscopy, UV-vis spectroscopy, TGA and BET isotherm analysis. The reactivity of the incorporated palladium(II) catalyst was tested in the in situ carbonylation of aryl iodides and secondary cyclic amines to the respective α-ketoamides at 80 °C. A large number of aryl iodides combined with CO followed by 2° amines can generate the corresponding α-ketoamides with high selectivity. This Pd(II) complex catalyst exhibits superb catalytic activities and can also be easily recovered after the reaction by an easy filtration method. The catalyst could be reused for up to six consecutive cycles without much loss in its activity.