Metal–organic framework mediated expeditious synthesis of benzimidazole and benzothiazole derivatives through an oxidative cyclization pathway

Abstract

Herein, we report the facile synthesis of various benzimidazoles and benzothiazoles by using the NH₂-MIL-125(Ti) MOF as an efficient oxidant-free heterogeneous catalyst with good yield. Adsorption of the substrate on the NH₂-MIL-125(Ti) MOF surface through electron deficient Ti⁴⁺ sites initiates the reaction. The broad substrate scope and high reusability of this catalyst are attractive for synthesis of a wide range of medicinally active benzimidazole and benzothiazole derivatives.