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Issue 9, 2020
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Biokinetics and clearance of inhaled gold ultrasmall-in-nano architectures

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Abstract

Among an organism's entry portals, the respiratory tract is one of the most promising routes for non-invasive administration of therapeutics for local and systemic delivery. On the other hand, it is the subtlest to protect from environmental pollution and microbial occurrences. Here, the biokinetics, distribution, and clearance trends of gold ultrasmall-in-nano architectures administered through a single intranasal application have been quantitatively evaluated. Apart from reaching the lung parenchyma, the (bio)degradable nano-architectures are able to translocate as well to secondary organs and be almost completely excreted within 10 days. These findings further support the clinical relevance of plasmonic nanomaterials for oncology and infectious disease treatment and management. Notably, this investigation also provides crucial information regarding the associated risks as a consequence of the pulmonary delivery of nanoparticles.

Graphical abstract: Biokinetics and clearance of inhaled gold ultrasmall-in-nano architectures

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Supplementary files

Article information


Submitted
24 Jun 2020
Accepted
22 Jul 2020
First published
22 Jul 2020

This article is Open Access

Nanoscale Adv., 2020,2, 3815-3820
Article type
Communication

Biokinetics and clearance of inhaled gold ultrasmall-in-nano architectures

A. K. Mapanao, G. Giannone, M. Summa, M. L. Ermini, A. Zamborlin, M. Santi, D. Cassano, R. Bertorelli and V. Voliani, Nanoscale Adv., 2020, 2, 3815
DOI: 10.1039/D0NA00521E

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