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Issue 12, 2020
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Indole – a promising pharmacophore in recent antiviral drug discovery

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Abstract

The bicyclic molecule indole has been in the limelight because of its numerous pharmacological potencies. It is used as an excellent scaffold in drug discovery of medicinal drugs such as antimicrobials, anticancer agents, antihypertensives, anti-proliferative agents and anti-inflammatory agents. In spite of its diverse therapeutic activity, it is used as a key pharmacophore in synthesizing the most potent biological agents. Besides, viral infections are ubiquitous and their prevention and cure have become a great challenge. In this regard, the design of indole-containing antiviral drugs is accomplished to combat viral infections. A lot of research is being carried out towards antiviral drug discovery by many researchers round the clock. Herein, the antiviral activity of recently discovered indole scaffolds is compiled and critically evaluated to give a meaningful summary. In addition, the structure–activity relationship of remarkable antiviral agents is discussed. Also, the structural motifs attributed to noteworthy antiviral properties are highlighted to guide future antiviral research.

Graphical abstract: Indole – a promising pharmacophore in recent antiviral drug discovery

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Article information


Submitted
10 Aug 2020
Accepted
04 Oct 2020
First published
06 Nov 2020

RSC Med. Chem., 2020,11, 1335-1353
Article type
Review Article

Indole – a promising pharmacophore in recent antiviral drug discovery

A. Dorababu, RSC Med. Chem., 2020, 11, 1335
DOI: 10.1039/D0MD00288G

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