Issue 9, 2020

Novel peptide-directed liposomes for targeted combination therapy of breast tumors

Abstract

Delivery and accumulation of therapeutic drugs into neoplastic cells distant from tumor vessels is a major challenge for antitumor therapy. Herein, we introduced a de novo peptide, p12 (QGSRRRNTVDDWISRRRALC), to conjugate onto the surface of doxorubicin (DOX) and indocyanine green (ICG) co-encapsulated nanoscale liposomes (pLipo-DOX–ICG). The p12 peptide triggered specific binding to CXC chemokine receptor 4 (CXCR4), leading to enhanced cellular uptake and improved accumulation of pLipo-DOX–ICG in CXCR4-overexpressing cancer cells. Moreover, the introduction of ICG molecules endowed pLipo-DOX–ICG with photothermal-induced structural disruption, which may be helpful for the precise and controllable release of doxorubicin at tumor tissue sites in vivo. With these advantages, the constructed pLipo-DOX–ICG demonstrated active targeting behavior for delivery and release of chemotherapeutic drugs, thereby showing much enhanced metastasis inhibition and antitumor efficacy than either drug-containing liposomes without p12 modification or free drugs in breast cancer bearing mice models. Overall, pLipo-DOX–ICG with low toxicity is expected to be a potential therapeutic agent to improve clinical benefits of breast cancer therapies, as well as treatment of a variety of CXCR4-overexpressing malignancies.

Graphical abstract: Novel peptide-directed liposomes for targeted combination therapy of breast tumors

Supplementary files

Article information

Article type
Paper
Submitted
23 Jul 2020
Accepted
02 Nov 2020
First published
04 Nov 2020
This article is Open Access
Creative Commons BY-NC license

Mater. Adv., 2020,1, 3483-3495

Novel peptide-directed liposomes for targeted combination therapy of breast tumors

K. Zhang, X. Fang, Q. You, Y. Lin, L. Ma, S. Xu, Y. Ge, H. Xu, Y. Yang and C. Wang, Mater. Adv., 2020, 1, 3483 DOI: 10.1039/D0MA00536C

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