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Issue 17, 2020
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Mechanochemical synthesis of (hetero)aryl Au(i) complexes

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Abstract

Growing demand for sustainable chemical syntheses casts mechanochemistry in a new light as an environmentally benign alternative to traditional solvent-based methods. Given recent interest in Au(I) complexes for catalytic, materials, and medicinal applications, we developed a mechanochemical protocol to prepare (hetero)aryl Au(I) complexes under green conditions. The procedure reported here uses C–H or C–B activation to afford the corresponding Au(I) complexes in high yields. Our approach bypasses external heating, long reaction times and the use of toxic solvents. We demonstrate that mechanochemical C–H auration can be used on highly functionalised bioactive substrates. Mechanistic aspects of the C–H auration are discussed.

Graphical abstract: Mechanochemical synthesis of (hetero)aryl Au(i) complexes

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Supplementary files

Article information


Submitted
02 Jul 2020
Accepted
11 Aug 2020
First published
11 Aug 2020

This article is Open Access

Green Chem., 2020,22, 5648-5655
Article type
Paper

Mechanochemical synthesis of (hetero)aryl Au(I) complexes

F. J. L. Ingner, Z. X. Giustra, S. Novosedlik, A. Orthaber, P. J. Gates, C. Dyrager and L. T. Pilarski, Green Chem., 2020, 22, 5648
DOI: 10.1039/D0GC02263B

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