Issue 5, 2020

Cobalt catalyzed electrochemical [4 + 2] annulation for the synthesis of sultams

Abstract

Cobalt catalyzed electrochemical [4 + 2] annulation of sulfonamides with alkynes is demonstrated in this work, which provided a practical and environmentally friendly way to synthesize structurally diverse sultams. Notably, by employing anodic oxidation in an undivided cell to recycle the cobalt catalyst, this electrochemical method avoided the utilization of stoichiometric amount of metallic oxidant, delivering H2 as the sole by-product. Moreover, this cobalt catalyzed electrochemical protocol proved to be practical and scalable. When the model reaction was scaled up to 5.0 mmol, 86% yield of product could still be obtained.

Graphical abstract: Cobalt catalyzed electrochemical [4 + 2] annulation for the synthesis of sultams

Supplementary files

Article information

Article type
Communication
Submitted
23 Jan 2020
Accepted
06 Feb 2020
First published
07 Feb 2020

Green Chem., 2020,22, 1548-1552

Cobalt catalyzed electrochemical [4 + 2] annulation for the synthesis of sultams

Y. Cao, Y. Yuan, Y. Lin, X. Jiang, Y. Weng, T. Wang, F. Bu, L. Zeng and A. Lei, Green Chem., 2020, 22, 1548 DOI: 10.1039/D0GC00289E

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