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Issue 10, 2020
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Two polyphenol-rich Brazilian fruit extracts protect from diet-induced obesity and hepatic steatosis in mice

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Abstract

Consumption of polyphenol-rich food is associated with better metabolic health. Tucum-do-Pantanal (Bactris setosa Mart) and taruma-do-cerrado (Vitex cymosa Bertero ex Spreng) are underexploited native Brazilian fruits with an important source of phytochemicals. In this study, we assessed the effects of 100 mg kg−1 tucum (TPE) and taruma (TCE) extracts on diet-induced obesity (DIO) C57BL/6J mice. After 8 weeks of daily treatment, TPE and TCE were found to significantly prevented the diet-induced body weight gain and fully protected against hepatic steatosis associated with a tendency to stimulate hepatic AMPK phosphorylation. TPE reduced visceral obesity and improved glucose metabolism as revealed by an improvement of the insulin tolerance test, a reduction in the insulin fasting level, and a decreased glucose-induced hyperinsulinemia during an oral glucose tolerance test. TPE and TCE showed promising effects on the treatment of obesity and NAFLD, furthermore, TPE on insulin resistance.

Graphical abstract: Two polyphenol-rich Brazilian fruit extracts protect from diet-induced obesity and hepatic steatosis in mice

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Article information


Submitted
21 Jul 2020
Accepted
10 Sep 2020
First published
15 Sep 2020

Food Funct., 2020,11, 8800-8810
Article type
Paper

Two polyphenol-rich Brazilian fruit extracts protect from diet-induced obesity and hepatic steatosis in mice

C. R. Ballard, E. F. dos Santos, M. Dubois, G. Pilon, C. B. B. Cazarin, M. R. Maróstica Junior and A. Marette, Food Funct., 2020, 11, 8800
DOI: 10.1039/D0FO01912G

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