Jump to main content
Jump to site search

Issue 10, 2020
Previous Article Next Article

Matcha green tea prevents obesity-induced hypothalamic inflammation via suppressing the JAK2/STAT3 signaling pathway

Author affiliations

Abstract

Obesity is an increasingly severe global health problem, leading to chronic inflammation and metabolic disorders in both peripheral tissues and the central nervous system. Matcha is a powdered green tea, and it is very popular in recent years as a beverage and food additive. Matcha green tea has been reported to have outstanding potential in regulating obesity-related metabolic syndrome. However, there are few studies on the regulation mechanism of matcha green tea on the central nervous system. In this study, we established a high-fat diet-induced obese mouse model. The results showed that dietary supplementation with matcha could effectively inhibit the weight gain, fat accumulation, glycemia and lipidemia increase, and excessive activation of microglia in the arcuate nucleus of the hypothalamus. Furthermore, we used different concentrations (100%, 80%, 60%, 40%, and 20%, v/v) of ethanol solution to prepare matcha ethanol extracts, and investigated their effects on palmitic acid-induced inflammation of microglial BV-2 cells. The results showed that matcha ethanol extracts could significantly reduce the release of inflammatory cytokines and the expression and phosphorylation of JAK2 and STAT3.

Graphical abstract: Matcha green tea prevents obesity-induced hypothalamic inflammation via suppressing the JAK2/STAT3 signaling pathway

Back to tab navigation

Article information


Submitted
09 Jun 2020
Accepted
03 Sep 2020
First published
01 Oct 2020

Food Funct., 2020,11, 8987-8995
Article type
Paper

Matcha green tea prevents obesity-induced hypothalamic inflammation via suppressing the JAK2/STAT3 signaling pathway

J. Zhou, H. Lin, P. Xu, L. Yao, Q. Xie, L. Mao and Y. Wang, Food Funct., 2020, 11, 8987
DOI: 10.1039/D0FO01500H

Social activity

Search articles by author

Spotlight

Advertisements