Interaction of macrocyclic gadolinium-based MR contrast agents with Type I collagen. Equilibrium and kinetic studies

Nicol Guidolin; Fabio Travagin; Giovanni B. Giovenzana; Adrienn Vágner; Sophia Lotti; Federica Chianale; Ernő Brücher; Federico Maisano; Miles A. Kirchin; Fabio Tedoldi; Alice Giorgini; Sonia Colombo Serra; Zsolt Baranyai

doi:10.1039/D0DT03314F

Interaction of macrocyclic gadolinium-based MR contrast agents with Type I collagen. Equilibrium and kinetic studies†

Nicol Guidolin,^a Fabio Travagin,

^b Giovanni B. Giovenzana,

^b Adrienn Vágner,^c Sophia Lotti,

^a Federica Chianale,^a Ernő Brücher,^c Federico Maisano,

^a Miles A. Kirchin,

^a Fabio Tedoldi,^a Alice Giorgini,

^a Sonia Colombo Serra^a and Zsolt Baranyai

*^a

Author affiliations

* Corresponding authors

^a Bracco Imaging Spa, Bracco Research Centre, Via Ribes 5, 10010 Colleretto Giacosa (TO), Italy
E-mail: zsolt.baranyai@bracco.com
Fax: +390403757830
Tel: +39 0403757842

^b Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Largo Donegani 2/3, Novara, Italy

^c Department of Inorganic and Analytical Chemistry, University of Debrecen, Egyetem tér 1., H-4032 Debrecen, Hungary

Abstract

The interactions of gadoterate meglumine, gadobutrol, gadoteridol and Gd(HB-DO3A) with bovine Type I collagen were investigated by ultrafiltration and dialysis. The affinity of the four agents to collagen is similar. However, the maximum adsorbed amount of Gd^III-complexes decreases in the following order: gadoterate meglumine > gadobutrol > gadoteridol > Gd(HB-DO3A). Calculations with the open three-compartment model reveal that the structural homologs gadoteridol and Gd(HB-DO3A) have a lower adsorption onto collagen, which may explain the less prolonged in vivo retention of gadoteridol observed in soft tissues of rats.

Dalton Transactions

Interaction of macrocyclic gadolinium-based MR contrast agents with Type I collagen. Equilibrium and kinetic studies†

Abstract

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Interaction of macrocyclic gadolinium-based MR contrast agents with Type I collagen. Equilibrium and kinetic studies

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