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Issue 1, 2020
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Recent advances in copper-catalysed radical-involved asymmetric 1,2-difunctionalization of alkenes

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Abstract

The radical-involved 1,2-difunctionalization of alkenes has developed into a robust tool for preparation of complex organic molecules. Despite significant advances in this area, the catalytic asymmetric version still remains a challenging task mainly due to the difficulty in the stereocontrol of the highly reactive radical intermediates. Recently, owing to the good single-electron transfer ability and coordination with chiral ligands of copper catalysts, remarkable achievements in radical-involved asymmetric alkene difunctionalization have been made via synergistic combination of copper and chiral ligands. This tutorial review highlights the recent progress in copper-catalysed radical-involved asymmetric 1,2-difunctionalization of alkenes and the mechanistic scenarios governing the stereocontrol, with an emphasis on utilization of chiral ligands.

Graphical abstract: Recent advances in copper-catalysed radical-involved asymmetric 1,2-difunctionalization of alkenes

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Article information


Submitted
30 Sep 2019
First published
05 Dec 2019

Chem. Soc. Rev., 2020,49, 32-48
Article type
Tutorial Review

Recent advances in copper-catalysed radical-involved asymmetric 1,2-difunctionalization of alkenes

Z. Li, G. Fang, Q. Gu and X. Liu, Chem. Soc. Rev., 2020, 49, 32
DOI: 10.1039/C9CS00681H

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