Issue 14, 2020

Nanotechnology for angiogenesis: opportunities and challenges

Abstract

Angiogenesis plays a critical role within the human body, from the early stages of life (i.e., embryonic development) to life-threatening diseases (e.g., cancer, heart attack, stroke, wound healing). Many pharmaceutical companies have expended huge efforts on both stimulation and inhibition of angiogenesis. During the last decade, the nanotechnology revolution has made a great impact in medicine, and regulatory approvals are starting to be achieved for nanomedicines to treat a wide range of diseases. Angiogenesis therapies involve the inhibition of angiogenesis in oncology and ophthalmology, and stimulation of angiogenesis in wound healing and tissue engineering. This review aims to summarize nanotechnology-based strategies that have been explored in the broad area of angiogenesis. Lipid-based, carbon-based and polymeric nanoparticles, and a wide range of inorganic and metallic nanoparticles are covered in detail. Theranostic and imaging approaches can be facilitated by nanoparticles. Many preparations have been reported to have a bimodal effect where they stimulate angiogenesis at low dose and inhibit it at higher doses.

Graphical abstract: Nanotechnology for angiogenesis: opportunities and challenges

Article information

Article type
Review Article
Submitted
23 Oct 2019
First published
15 Jun 2020

Chem. Soc. Rev., 2020,49, 5008-5057

Nanotechnology for angiogenesis: opportunities and challenges

S. Kargozar, F. Baino, S. Hamzehlou, M. R. Hamblin and M. Mozafari, Chem. Soc. Rev., 2020, 49, 5008 DOI: 10.1039/C8CS01021H

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