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Mechanochemical approaches towards the in situ confinement of 5-FU anti-cancer drug within MIL-100 (Fe) metal–organic framework

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Abstract

We elucidate two annealing assisted mechanochemical methods to achieve one-pot encapsulation of anti-cancer drug 5-fluorouracil (5-FU) in the iron-based MIL-100 metal–organic framework (MOF). We compare the structural and physicochemical properties of drug@MIL-100 systems derived from in situ manual and vortex grinding, where the former technique exhibits a slower drug release due to stronger guest–host interactions.

Graphical abstract: Mechanochemical approaches towards the in situ confinement of 5-FU anti-cancer drug within MIL-100 (Fe) metal–organic framework

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Supplementary files

Article information


Submitted
28 Apr 2020
Accepted
29 Jun 2020
First published
29 Jun 2020

This article is Open Access

CrystEngComm, 2020, Advance Article
Article type
Communication

Mechanochemical approaches towards the in situ confinement of 5-FU anti-cancer drug within MIL-100 (Fe) metal–organic framework

B. E. Souza and J. Tan, CrystEngComm, 2020, Advance Article , DOI: 10.1039/D0CE00638F

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