pH/glutathione-responsive release of SO2 induced superoxide radical accumulation for gas therapy of cancer

Rui Gu; Lei Wang; Xiaoyu Huang; Jiayao Zhang; Changjin Ou; Weili Si; Jianguang Yu; Wenjun Wang; Xiaochen Dong

doi:10.1039/D0CC06826H

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pH/glutathione-responsive release of SO₂ induced superoxide radical accumulation for gas therapy of cancer†

Rui Gu,^a Lei Wang,^a Xiaoyu Huang,^a Jiayao Zhang,^a Changjin Ou,^a Weili Si,

*^a Jianguang Yu,*^b Wenjun Wang^c and Xiaochen Dong

*^ad

Author affiliations

* Corresponding authors

^a Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing, China
E-mail: iamxcdong@njtech.edu.cn, iamwlsi@njtech.edu.cn

^b College of Food Science and Light Industry, Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211800, China
E-mail: yjg@njtech.edu.cn

^c School of Physical Science and Information Technology, Liaocheng University, Liaocheng 252059, China

^d School of Chemistry and Materials Science, Nanjing University of Information Science & Technology, Nanjing 210044, China

Abstract

A pH/GSH-responsive SO₂ generation nanoplatform (BODS NPs) is established to achieve lysosomal escape and GSH depletion in tumor cells. O₂˙⁻ as the main ROS during SO₂-mediated gas therapy can be accumulated through Cu/Zn-SOD enzymatic activity suppression and mitochondrial biogenesis, further exacerbating the oxidative stress and resulting in cell apoptosis.

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Article information

DOI: https://doi.org/10.1039/D0CC06826H
Article type: Communication
Submitted: 13 Oct 2020
Accepted: 02 Nov 2020
First published: 03 Nov 2020

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Chem. Commun., 2020,56, 14865-14868

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pH/glutathione-responsive release of SO₂ induced superoxide radical accumulation for gas therapy of cancer

R. Gu, L. Wang, X. Huang, J. Zhang, C. Ou, W. Si, J. Yu, W. Wang and X. Dong, Chem. Commun., 2020, 56, 14865 DOI: 10.1039/D0CC06826H

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Chemical Communications