A self-accelerated biocatalyst for glucose-initiated tumor starvation and chemodynamic therapy

Fuan Deng; Guiling Fan; Ping Yuan; Yibin Liu; Chuyu Huang; Linping Zhao; Xin Wang; Xiyong Yu; Hong Cheng; Shiying Li

doi:10.1039/D0CC06483A

A self-accelerated biocatalyst for glucose-initiated tumor starvation and chemodynamic therapy†

Fuan Deng,^a Guiling Fan,^a Ping Yuan,^a Yibin Liu,^a Chuyu Huang,^a Linping Zhao,^a Xin Wang,^b Xiyong Yu,^a Hong Cheng

*^c and Shiying Li

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, P. R. China
E-mail: lisy-sci@gzhmu.edu.cn

^b The Sixth Affiliated Hospital of Guangzhou Medical University, Guangzhou 511436, P. R. China

^c Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, P. R. China
E-mail: chengh@smu.edu.cn

Abstract

A self-accelerated biocatalyst (Bio-Cat) was developed based on BSA and GOx crosslinked nanoproteins for glucose-initiated tumor starvation and chemodynamic therapy. Bio-Cat could catalyze the glucose to elevate the intracellular H₂O₂ level and accelerate the conversion of Fe³⁺/Fe²⁺, resulting in an effective starvation therapy and an accelerated Fenton reaction for chemodynamic therapy.

Chemical Communications

A self-accelerated biocatalyst for glucose-initiated tumor starvation and chemodynamic therapy†

Abstract

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A self-accelerated biocatalyst for glucose-initiated tumor starvation and chemodynamic therapy

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