Issue 90, 2020
From the journal:

Chemical Communications

A hydrophilic magnetic MOF for the consecutive enrichment of exosomes and exosomal phosphopeptides†‡

Ning Zhang,a   Nianrong Sun ORCID logo *b  and  Chunhui Deng ORCID logo *abc  

* Corresponding authors

a Department of Chemistry, Fudan University, Shanghai, China
E-mail: sunnianrong@fudan.edu.cn

b Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China

c Institutes of Biomedical Sciences, Collaborative Innovation Center of Genetics and Development, Fudan University, Shanghai, China
E-mail: chdeng@fudan.edu.cn

Abstract

Hydrophilic Fe3O4@PDA@UIO-66-NH2 is employed to consecutively enrich urinary exosomes and exosomal phosphopeptides through the strong bond between Zr and phosphate groups. The recovery of exosomes reached 95% and 707 phosphopeptides were identified from 255 phosphoproteins via LC-MS/MS. This work will make a great contribution to further functional analysis of exosomes.

Graphical abstract: A hydrophilic magnetic MOF for the consecutive enrichment of exosomes and exosomal phosphopeptides

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Article information

DOI
https://doi.org/10.1039/D0CC06147F
Article type
Communication
Submitted
11 Sep 2020
Accepted
07 Oct 2020
First published
07 Oct 2020

Chem. Commun., 2020,56, 13999-14002

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A hydrophilic magnetic MOF for the consecutive enrichment of exosomes and exosomal phosphopeptides

N. Zhang, N. Sun and C. Deng, Chem. Commun., 2020, 56, 13999 DOI: 10.1039/D0CC06147F

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